TOYOPEARL NH2-750F, >1.000 Å, salt tolerant, 100mL

Tosoh Bioscience has developed the salt tolerant anion exchange resin, TOYOPEARL NH2-750F, offering high binding capacity across a range of pH values and conductivities. A TOYOPEARL HW-75 polymeric bead has been functionalized with a primary amine-containing ligand resulting in a resin with increased salt tolerance and selectivity different than that of quaternary amine anion exchange resinscurrently available. This resin is ideal for process scale applications from the capture of proteins from biological feedstock (mammalian cell culture, plasma, bacterial feedstock, etc.) without dilution to the intermediate or final purification of monoclonal antibodies (mAbs) where aggregates and other impurities are removed from the target of interest. TOYOPEARL NH2-750F is capable of post-protein A removal of aggregates in both, flow-through and bind/elute modes